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Algae-Based Biopharmaceuticals
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Algae-Based Biopharmaceuticals
von: Sergio Rosales-Mendoza
Springer-Verlag, 2016
ISBN: 9783319322322
172 Seiten, Download: 5326 KB
 
Format:  PDF
geeignet für: Apple iPad, Android Tablet PC's Online-Lesen PC, MAC, Laptop

Typ: B (paralleler Zugriff)

 

 
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Inhaltsverzeichnis

  Preface 6  
  Contents 8  
  Chapter 1: The Biopharmaceuticals Field and Algae as Expression Hosts 12  
      Introduction 12  
      Biopharmaceuticals Market and Current Limitations 14  
      Current Platforms for the Large-Scale Production of BFs 16  
      General Features of Microalgae 17  
      Features of Algae and Implications in BFs Production 18  
      Relevant Algae Species 20  
         Phaeodactylum tricornutum 20  
         Dunaliella salina 21  
         Chlamydomonas reinhardtii 21  
         Schizochytrium sp. 21  
      Prospective View 22  
     References 22  
  Chapter 2: Genetic Engineering Approaches for Algae 26  
      Introduction 26  
      Construction of Genes and Expression Vectors 27  
      Transformation Techniques 31  
         Agrobacterium tumefaciens 31  
         Biolistic 33  
         Glass Beads Treatment 34  
         Electroporation 34  
      Expression Modalities 34  
         Nuclear and Chloroplast-Based Expression 34  
         Inducible Expression 35  
      Overview of Algae Transformation Achievements 37  
      Advances for Transgene Expression in the Model Alga C. reiinhardtii 39  
         Multigene Expression and Organelle Targeting 39  
      Generation of Mutant Strains with High Productivity 44  
      Fusion to Protein Partners 45  
      The Transformosome Concept 45  
      Prospective View 46  
     References 46  
  Chapter 3: Algae-Made Vaccines Targeting Human Diseases 52  
      Introduction 52  
      Gut Associated Immune System and Oral Vaccination 53  
      Vaccines Targeting Infectious Agents 57  
         Plasmodium falciparum 57  
         Staphylococcus aureus 60  
         Human Papillomavirus 60  
         Influenza Virus 61  
         Hepatitis B Virus 64  
         Human Immunodeficiency Virus 65  
      Vaccines Targeting Non-communicable Diseases 66  
         Type I Diabetes 66  
         Atherosclerosis 66  
         Hypertension 66  
         Allergy 67  
      Prospective View 67  
     References 70  
  Chapter 4: Algae-Made Vaccines Targeting Animal Pathogens 75  
      Introduction 75  
      Algae-Based Vaccines 76  
         Classical Swine Fever Virus 76  
         White Spot Syndrome Virus 77  
         Taenia Solium 78  
         Foot-and-Mouth Disease Virus 79  
         Porcine Circovirus 80  
      Prospective View 80  
     References 83  
  Chapter 5: Algae-Made Antibodies and Immunotoxins 86  
      Introduction 86  
      Current Developments on Algae-Made Antibodies and Immunotoxins 88  
         Large Single-Chain (lsc) Antibody Against Herpes Simplex Virus (HSV) Glycoprotein D 88  
      Full-Length Antibodies Against the Anthrax Protective Antigen 83 91  
      An Anti-hepatitis B Surface Protein Antibody Produced in Phaeodactylum tricornutum 92  
      Camelid Antibodies Against Botulinum Neurotoxin Serotype A (BoNT/A) 93  
      Immunotoxins Targeting CD22+ Cells 94  
      Prospective View 97  
     References 100  
  Chapter 6: Algae-Made Cytokines and Growth Factors 103  
      Introduction 103  
      Section I 104  
         Human Interferon ?1 104  
         Human Vascular Endothelial Growth Factor 106  
         High Mobility Group Protein B1 107  
      Section II 108  
         Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand 108  
         Tumor Necrosis Factor Alpha Produced in Dunaliella salina 109  
         C. reinhardtii Secreting VEGF for the Development of Photosynthetic Biomaterials in Tissue Engineering 110  
         Prospective View 110  
     References 113  
  Chapter 7: Other Biopharmaceuticals Produced in Algae 117  
      Introduction 117  
      Antimicrobial Peptides 117  
         Rabbit Neutrophil Peptide-1 117  
      Lactoferricin 118  
      Fibronectin Domains 119  
      Soybean Kunitz Trypsin Inhibitor 121  
      Hormones 122  
         Erythropoietin 122  
      Human Growth Hormone 124  
      Flounder Growth Hormone 124  
      Prospective View 125  
     References 126  
  Chapter 8: Algae-Made Nutraceuticals Produced Using Genetic Engineering Approaches 129  
      Introduction 129  
      Proteins 130  
         Bovine Milk Amyloid A Produced in C. reinhardtii 130  
      A Chimeric Protein Carrying Bioactive Peptides Produced in C. reinhardtii 136  
      Lipids 137  
      Carotenoids 139  
      Prospective View 143  
     References 145  
  Chapter 9: Perspectives for the Algae-Made Biopharmaceuticals Field 150  
      Introduction 150  
      Key Perspectives for the Field of Producing BFs in Microalgae 151  
         Optimizing Nuclear Expression 151  
      Implementing Glycoengineering Approaches 153  
      Exploring New Approaches for Oral Delivery 156  
      Optimizing Large-Scale Production in Bioreactors 157  
      Expanding the Group of Species Used as Hosts 162  
      Technology Transfer and Regulatory Approval 163  
     References 165  
  Index 171  


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